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维持正常的房水流出(AHO)是眼内细胞健康和视力稳定至关重要的因素。AHO的损伤可导致眼压升高、神经损伤并伴随青光眼的发生。了解AHO能更好地指导青光眼手术，促进AHO靶向药物的研发，进而改善AHO的功能。AHO通道造影是一种与荧光素眼底血管造影类似的、应用荧光素或吲哚菁绿辅助显影AHO的眼前节造影技术，但其成像的是房水的排出轨迹而不是血流的运动。将造影剂引入前房，经房水循环，追踪造影剂的运动轨迹，捕捉围绕角膜缘360° AHO图像信息，可获得实时、动态的AHO影像资料。研究者先后研究了不同物种离体眼球的AHO特点，实时观察了非人灵长类动物活体眼球AHO的动态变化，并在此基础上，进一步研究了人活体眼球房水引流的运动轨迹及变化特点。AHO通道造影技术作为一种AHO功能评估的新工具，为AHO功能研究提供了新方法，但其作为一种侵入性的检查方法，研究过程中存在很多限制因素。为了更好地理解该技术，本文就AHO通道造影技术的发生和发展及现状进行综述。“,”Maintaining normal aqueous humor outflow (AHO) is important for intraocular cellular health and vision stabilization.AHO impairment may lead to increased intraocular pressure, optic nerve damage, and concomitant glaucoma.A heightend understanding of AHO will help to improve the glaucoma surgeries that enhance native AHO and will facilitate the development of AHO-targeted pharmaceuticals.Aqueous angiography of AHO is an anterior segment angiography technique similar to fundus fluorescein angiography.It uses fluorescein or indocyanine green to assist AHO, but the trajectory of the aqueous humor is imaged, rather than the movement of blood flow.The contrast agent is introduced into the anterior chamber, and its trajectory is tracked through the aqueous humor cycle to capture 360° aqueous effluent outflow information around the limbus and obtain real-time and dynamic AHO image data.The researchers studied the AHO characteristics of different species of isolated eyeballs and observed the dynamic changes of AHO in non-human primates.Based on this, the trajectory and characteristics of the drainage of live human aqueous humor were further studied.Aqueous humor angiography, as a new tool for AHO functional assessment, has brought new research to AHO functions.However, as it is an invasive examination method, there are many limiting factors in the research process.To better understand the technology, this article reviews the emergence, progress, and current status of aqueous angiography.