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近年来神经干细胞(neural stem cells,NSCs)移植治疗神经系统疾病成为研究热点之一,但NSCs的来源困难,并且存在伦理学争议,这在很大程度上限制了干细胞移植应用的发展。研究发现骨髓间充质干细胞(bone mesen-chymal stem cells,BMSCs)在细胞因子、化学试剂、共培养、药物诱导下具有向神经元样细胞(Neural-Like Cells)分化的能力,因而成为干细胞的主要来源。本文就近年BMSCs体外诱导分化为神经元样细胞的研究方案作一综述。
In recent years, the transplantation of neural stem cells (NSCs) has become one of the hot topics in the field of neurological diseases. However, the sources of NSCs are difficult and have ethical controversy, which greatly limits the development of stem cell transplantation. It has been found that bone marrow mesenchymal stem cells (BMSCs) have the ability to differentiate into neural-like cells under the guidance of cytokines, chemical reagents, co-culture and drugs and thus become stem cells The main source. In this paper, BMSCs in vitro induction of differentiation into neuron-like cells in recent research programs are reviewed.