【摘 要】
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目的 在女性人群中探讨亚临床甲减与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的关系.方法 选取200例女性NAFLD患者(NAFLD组)和200例健康体检女性(正常
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目的 在女性人群中探讨亚临床甲减与非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)的关系.方法 选取200例女性NAFLD患者(NAFLD组)和200例健康体检女性(正常对照组),对入选者进行体格检查、肝脏彩色超声检查及血脂、血糖、甲状腺功能等相关指标的测定.结果 与对照组相比,NAFLD组BMI、TC、TG、LDL-C、FBG、ALT、AST、GGT、TSH和亚临床甲减发生率均升高,而HDL-C低于对照组(P均<0.05);Logistic回归分析提示TSH(OR=2.006,95%CI:1.545~2.694,P=0.003)和亚临床甲减(OR= 1.993,95%CI:1.415~2.787,P=0.005)均是NAFLD 发生的独立危险因素;按照TSH水平三分位数将所有研究对象分成三组,结果提示,随着TSH水平的升高,NAFLD发生率逐渐升高(70.8%vs68.7%vs53.9%,P<0.01).结论 在女性人群中,亚临床甲减与NAFLD密切相关.
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