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目的:观察慢性肺源性心脏病急性加重期和缓解期患者凝血功能与棘形红细胞变化的关系。方法:使用凝固法检测55例慢性肺源性心脏病患者急性加重期和缓解期血浆凝血酶原时间、活化部分凝血活酶时间、凝血酶时间、纤维蛋白原,同时用电镜观察其静脉血液中的棘形红细胞。结果:缓解期凝血酶原时间、活化部分凝血活酶时间较急性加重期均明显延长(P<0.01),凝血酶时间较急性加重期缩短(P<0.01),纤维蛋白原水平降低(P<0.01),棘形红细胞减少明显(P<0.01)。结论:慢性肺源性心脏病病情好转与凝血功能恢复及棘形红细胞比例减少呈正相关,凝血功能及棘形红细胞的检测对慢性肺源性心脏病预后有重要意义。
Objective: To observe the relationship between coagulation function and changes of splenocytes in patients with chronic cor pulmonale during acute exacerbation and remission. Methods: The coagulation method was used to detect the plasma prothrombin time, partial thromboplastin time, thrombin time and fibrinogen in 55 patients with chronic cor pulmonale during acute exacerbation and remission, Spike-shaped red blood cells. Results: Prothrombin time and activated partial thromboplastin time in remission stage were significantly longer than those in acute exacerbation stage (P <0.01), thrombin time was shorter than acute exacerbation stage (P <0.01) and fibrinogen level was lower (P < 0.01), decreased splenic erythrocytes (P <0.01). Conclusion: The improvement of chronic cor pulmonale has positive correlation with the recovery of coagulation and the decrease of the ratio of splenic erythrocytes. The detection of coagulation and splenic erythrocytes is of great significance for the prognosis of chronic cor pulmonale.