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应用单向免疫扩散法对34例阵发性睡眠性血红蛋尿(PNH)病人的血浆纤维结合蛋白(FN)进行测定。结果表明,PNH 病人血浆 FN 水平显著低于正常人。其下降幅度与病情有关,与血浆游离血红蛋白呈负相关,与血红蛋白及触珠蛋白呈正相关。提示动态观察血浆 FN 有助于 PNH 病人溶血程度的估计。
34 cases of paroxysmal nocturnal hemoglobin (PNH) in patients with plasma fibronectin (FN) were measured by one-way immunodiffusion. The results showed that PNH patients with plasma FN levels were significantly lower than normal. The decrease was related to the disease, negatively correlated with plasma free hemoglobin, and positively correlated with hemoglobin and haptoglobin. It is suggested that the dynamic observation of plasma FN contributes to the estimation of hemolysis in PNH patients.