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作者看到两例大脑缺血的病人,未行抗凝治疗而部分凝血激酶时间(PTT)延长,患者既无系统性红斑狼疮(SLE)病史,又无异常出血倾向,但在患者血液中却发现了狼疮抗凝血因子。该因子由直接测定患者血浆 PTT 延长并通过加入在37℃放置1小时后的正常血浆不能矫正到正常而得到鉴定。
The authors saw two patients with cerebral ischemia who had no history of anticoagulant therapy and partial thromboplastin time (PTT). Patients had neither a history of systemic lupus erythematosus (SLE) nor an abnormal bleeding tendency, but in the patient’s blood Found lupus anticoagulant factor. This factor is prolonged by direct measurement of the patient’s plasma PTT and is identified by the inability of normal plasma to normalize after addition for one hour at 37 ° C.