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目的 :探讨原发性肾病综合征 (NS)患者的血栓前状态。方法 :对 48例NS患者血中的纤维蛋白原 ,(Fg)、活化部分凝血活酶时间 (APTT)、凝血酶原时间 (PT)、血液流变学、Plt计数进行监测。结果 :NS患者的Fg ,Plt计数均明显增高 ,APTT明显缩短 ,与正常对照组相比差异有显著意义 (P <0 .0 5 ) ;全血比黏度、血浆比黏度、红细胞压积明显增高 ,ESR明显增快 ,与正常对照组相比差异有显著意义 (P <0 .0 5 )。结论 :NS患者处于血栓前状态 ,有形成血栓的危险 ,Fg、APTT、Plt及血液流变学在血栓前状态的发生和发展起着重要的作用。
Objective: To investigate the prothrombotic state in patients with primary nephrotic syndrome (NS). Methods: Serum fibrinogen (Fg), activated partial thromboplastin time (APTT), prothrombin time (PT), hemorheology and Plt count were measured in 48 patients with NS. Results: The counts of Fg and Plt in patients with NS were significantly higher than those in normal controls (P <0.05), and the whole blood specific viscosity, plasma specific viscosity and hematocrit were significantly increased , ESR significantly increased, compared with the normal control group, the difference was significant (P <0. 05). Conclusion: Patients with NS are in a pre-thrombotic state with a risk of thrombosis. Fg, APTT, Plt and hemorheology play an important role in the occurrence and development of prothrombotic state.