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目的 探讨特发性震颤 (ET)的临床特点。方法 对 80例 ET患者的临床资料进行分析。结果80例 ET中男 5 0例 ,女 30例 ,发病年龄 3～ 70岁 ,平均 34.6± 16 .3岁 ,病程 6个月～ 6 0年 ,平均 14.2± 9.9年。45例 (5 6 .3% )患者有阳性家族史 ,多呈常染色体显性遗传。临床主要表现为单症状的姿势性震颤 ,累及部位依次为手 (92 .5 % )、咽喉部 (2 1.3% )、头 (2 0 % )、下颏 (17.5 % )等。 17.5 %患者因震颤致日常生活困难。 34例饮酒患者中 ,91.2 %显示对酒精有反应性。 6 .3%患者并发帕金森病 (PD)。 6 1%患者小剂量心得安治疗有效。结论 本组 ET患者男多于女 ,发病年龄轻 ,呈单峰模式 ,临床表现为单症状姿势性震颤 ,部分病例可伴发PD,小剂量心得安治疗大多有效。
Objective To investigate the clinical features of idiopathic tremor (ET). Methods The clinical data of 80 patients with ET were analyzed. Results 80 cases of ET in male 50 cases, 30 females, the age of onset of 3 to 70 years old, with an average of 34.6 ± 16.3 years, duration of 6 months to 60 years, an average of 14.2 ± 9.9 years. 45 cases (56.3%) patients had a positive family history, mostly autosomal dominant. The clinical manifestations of the single symptom postural tremor, involving the order of hand (92.5%), throat (21.3%), head (20%), chin (17.5%) and so on. 17.5% of patients had difficulty in daily life due to tremor. Among 34 alcoholics, 91.2% showed alcohol reactivity. Six.3% of patients complicated with Parkinson’s disease (PD). 6 1% of patients with low-dose propranolol therapy effective. Conclusions This group of patients with ET more than men, the age of onset was light, showing a unimodal pattern, the clinical manifestations of single symptoms postural tremor, some cases may be associated with PD, low-dose propranolol mostly effective.