栓剂是一种古老的药物剂型。它具备有不少治疗上独到的优点,因此,在目前也还是一种经常应用的药物剂型。栓剂在世界各地区的应用程度是不同的;在西欧应用最多,而亚洲、北美则用得较少。我国过去只是用栓剂治疗直肠、阴道的局部疾病,目前开始应用于全身治疗。过去的一些栓剂专著只阐述了栓剂给药的优点方面,缺少对栓剂给药的全面评价。在栓剂的生物利用度这样一个重要的问题上,还没有明确的定论。而前 Suppositories are an ancient form of medicine. It has many of the advantages of the treatment of unique, therefore, is still a commonly used form of the drug. Suppositories are used at different levels in different parts of the world, most widely in Western Europe, and less in Asia and North America. In the past, our country only used suppository to treat the local diseases of rectum and vagina, and now it is applied to systemic treatment. Some previous suppository monographs only described the advantages of suppository administration, lacking a complete assessment of suppository administration. There is no definitive conclusion on the important issue of suppository bioavailability. While ago