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目的:探讨HPV阴性与HPV阳性宫颈癌的临床特点及其和预后的关系。方法:选取住院手术的HPV呈阴性与阳性的宫颈癌患者各86例,且两组患者在年龄、FIGO临床分期相近。分析两组患者的年龄、肿瘤临床分期、病理分型、原发肿瘤大小、分化程度、基层浸润深度、淋巴结转移、治疗方案情况及其5年RFS和总生存时间。结果:两组间宫颈癌患者肿瘤分化程度、肌层浸润深度、淋巴结转移间差异有统计学意义(P<0.05)。HPV阳性组和HPV阴性组随访时间分别为63(13~87)个月、61(9~90)个月,5年总生存率分别为70.4%和61.3%,平均总生存时间分别为(73.15±2.74)月和(62.72±3.03)月,差异有统计学意义(p<0.05)。HPV阴性组和HPV阳性组5年RFS分别为52.3%和66.4%,平均RFS为(51.57±4.62)月和(58.83±3.46)月,差异有统计学意义(p<0.05)。结论:HPV阴性宫颈癌瘤体倾向于低分化,易发生局部侵犯和淋巴结转移,其临床预后较差。
Objective: To investigate the clinical features of HPV-negative and HPV-positive cervical cancer and its relationship with prognosis. Methods: Eighty-six patients with cervical cancer who were HPV negative and positive from hospitalization were selected, and the age of the two groups was similar to that of FIGO. The age, tumor clinical stage, pathological type, primary tumor size, differentiation, depth of primary infiltration, lymph node metastasis, treatment regimen, 5-year RFS and overall survival time were analyzed. Results: The differences of tumor differentiation, depth of myometrial invasion and lymph node metastasis between two groups were statistically significant (P <0.05). The mean follow-up time was 63 (13-87) months in patients with HPV-positive and 61-month (9-90) months, with a 5-year overall survival of 70.4% and 61.3%, respectively. The mean overall survival time was (73.15 ± 2.74 months) and (62.72 ± 3.03 months), the difference was statistically significant (p <0.05). The 5-year RFS of HPV-negative and HPV-positive patients were 52.3% and 66.4%, respectively. The average RFS was (51.57 ± 4.62) months and (58.83 ± 3.46) months, respectively. The difference was statistically significant (p <0.05). Conclusion: HPV-negative cervical carcinoma tends to be poorly differentiated, prone to local invasion and lymph node metastasis, and its clinical prognosis is poor.