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肿瘤血管生成是一个非常复杂的过程,涉及到多种因子的调节。目前,已发现多种糖基磷脂酰肌醇锚定蛋白质与肿瘤血管生成密切相关。尿激酶型纤溶酶原激活剂受体(urokinase plasminogen activator receptor,uPAR/CD87)、CD55、基质金属蛋白酶、T-钙黏着蛋白、RECK、Eph家族受体作用蛋白A(Eph family receptor interacting protein A,ephrin A)等均能调节肿瘤血管生成过程。本文对糖基磷脂酰肌醇锚定的调节因子如何影响肿瘤血管生成,以及它们作为肿瘤治疗的主要靶标研究进行综述,为肿瘤治疗的抗血管生成新靶标的设计提供信息。
Tumor angiogenesis is a very complex process involving the regulation of multiple factors. Currently, a variety of glycosylphosphatidylinositol-anchored proteins have been found to be closely associated with tumor angiogenesis. Urokinase plasminogen activator receptor (uPAR / CD87), CD55, matrix metalloproteinase, T-cadherin, RECK, Eph family receptor interacting protein A , ephrin A) can regulate tumor angiogenesis. Here we review how the regulatory factors of glycosylphosphatidylinositol anchorage affect tumor angiogenesis and their role as the primary targets for cancer therapy, providing information on the design of novel targets for anti-angiogenesis in cancer therapy.