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目的探讨血清肝细胞生长因子(HGF)在2型DM不同肾损害期中的变化、临床意义及糖尿病肾病发生发展中的作用。方法将2型DM患者92例分为不同的组别,其中尿白蛋白正常组30例,尿白蛋白微量组32例,尿白蛋白明显增高组30例;糖耐量异常患者33例,采用ELISA法检测血清HGF水平,同时用化学发光法检测尿微量白蛋白。结果糖耐量异常组和尿白蛋白正常组HGF浓度明显高于对照组(P<0.05);尿白蛋白微量组及尿白蛋白明显增高组HGF浓度明显低于对照组(P<0.05);且尿白蛋白明显增高组又显著低于尿白蛋白微量组(P<0.05)。结论2型DM患者不同肾损害期HGF浓度差别有统计学意义,检测血HGF水平可为糖尿病肾病的诊断和治疗监测提供可靠依据。
Objective To investigate the changes, clinical significance and the role of serum hepatocyte growth factor (HGF) in the development of diabetic nephropathy in type 2 DM patients during different stages of renal damage. Methods 92 patients with type 2 DM were divided into different groups, of which 30 cases were normal urine albumin, 32 cases urinary albumin micro-group and 30 cases urinary albumin were significantly increased; 33 cases were patients with impaired glucose tolerance, Method to detect serum HGF level, while using chemiluminescence detection of urine microalbumin. Results HGF concentrations in normal glucose tolerance group and normal urine albumin group were significantly higher than those in control group (P <0.05). HGF concentrations in urine albumin group and urine albumin group were significantly lower than those in control group (P <0.05) Urinary albumin significantly increased group was significantly lower than urinary albumin micro-group (P <0.05). Conclusions The difference of HGF concentration in patients with type 2 DM during different stages of renal damage has statistical significance. Detecting the level of HGF in blood can provide a reliable basis for the diagnosis and treatment of diabetic nephropathy.