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考察葛根素油基微乳在大鼠小肠的吸收动力学特征和最佳吸收部位,研究微乳的吸收转运通路。大鼠在体肠回流实验考察小肠吸收行为,通过阻断和未阻断淋巴液及药物浓度的变化确定吸收转运通路。葛根素油基微乳在各肠段均有吸收,各肠段的Ka、Papp大小顺序是回肠>十二指肠>空肠>结肠,且回肠的Ka、Papp值显著大于其他肠段,不同浓度的药物吸收速率差异不显著(P>0.05)。经胃肠道生物转运的葛根素中约有36.8%经淋巴途径进入体循环,63.2%经非淋巴途径吸收。葛根素微乳在回肠吸收最好,属被动转运;转运通路是淋巴和非淋巴转运。
The absorption kinetics and the best absorption sites of puerarin oil-based microemulsion in the rat small intestine were investigated to study the absorption and translocation pathway of microemulsion. Intestinal reflux experiments in rats were conducted to examine the absorption behavior of the small intestine, and the absorption and translocation pathways were determined by blocking and not blocking the changes of lymph fluid and drug concentration. The puerarin oil-based microemulsion was absorbed in all intestinal segments. The Ka, Papp order of each segment was ileum> duodenum> jejunum> colon, and Ka, Papp values of the ileum were significantly greater than those of other intestine segments. The difference in drug absorption rate was not significant (P>0.05). About 36.8% of the puerarin transported by the gastrointestinal tract enters the systemic circulation via the lymphatic pathway, and 63.2% is absorbed by the non-lymphatic pathway. Puerarin microemulsion absorbs best in the ileum and is passively transported; the transport pathway is lymphatic and non-lymphatic transport.