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目的:探讨糖尿病肾病(DN)患者内脏脂肪面积(VFA)与臂踝脉搏波传导速度(BAPWV)的关系。方法:选取大同大学附属第一医院(大同市第五人民医院)2018年9月至2019年3月住院治疗的2型糖尿病患者464例，根据尿白蛋白/肌酐比值(UACR)及血肌酐水平分为四组，尿蛋白正常组(UACR<30 mg/g)315例，微量白蛋白尿组(UACR 30～299 mg/g)72例，大量蛋白尿组(UACR≥300 mg/g)45例，肾功能衰竭组(血肌酐高于参考值)32例。前三组血肌酐在正常范围。比较四组血压、体质量指数(BMI)、VFA、皮下脂肪面积(SFA)、BAPWV、血脂、肾功能、血糖等指标，以VFA为应变量，其他指标为自变量，进行多元线性回归分析。结果:四组年龄、身高、体质量、BMI、头围、颈围、腰围、臀围、腰臀比差异均有统计学意义(n F＝15.580、4.679、6.186、3.553、3.153、2.689、5.170、3.114、3.515，均n P<0.05)；尿蛋白正常组、微量白蛋白尿组、大量蛋白尿组、肾功能衰竭组VFA分别为(102.25±37.09)cmn 2、(104.12±40.93)cmn 2、(119.63±48.82)cmn 2、(110.54±41.58)cmn 2，BAPWV分别为(1 546.97±330.18)cm/s、(1 595.52±381.27)cm/s、(1 459.63±285.61)cm/s、(1 703.89±318.64)cm/s，差异均有统计学意义(n F＝3.344、4.020，均n P<0.05)；四组丙氨酸氨基转移酶、血肌酐、血尿酸、总胆固醇、红细胞、血红蛋白、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)差异均有统计学意义(n F＝3.405、15.535、6.552、2.803、6.158、15.580、3.764、3.262，均n P<0.05)。以VFA为应变量，进行多元线性回归分析，结果显示腰围、BMI、TG、BAPWV与VFA均有相关性(均n P<0.05)。n 结论:DN与多个肥胖相关指标及炎症指标NLR、PLR有关，VFA与BAPWV有相关性。“,”Objective:To investigate the clinical characteristics of different stages of type 2 diabetic nephropathy(DN), and to explore the possible factors affecting visceral fat area (VFA).Methods:From September 2018 to March 2019, 464 patients with type 2 diabetes who were hospitalized in the First Affiliated Hospital of Datong University were selected.Among them, 315 patients with urinary albumin/creatinine ratio(UACR)300 mg/g were selected as massive proteinuria group, and 32 patients with serum creatinine higher than the reference value were selected as renal failure group.The serum creatinine of the first three groups was in the normal range.The clinical data of these patients such as blood pressure, body mass index(BMI), VFA, subcutaneous fat area(SFA), brachial-ankle pulse wave velocity(BAPWV), blood lipid, renal function and blood sugar were collected and compared among the four groups.Using VFA as strain and other indicators as independent variables, multivariate linear regression analysis was carried out.Results:There were statistically significant differences among the four groups in age, height, weight, BMI, head circumference, neck circumference, waist circumference, hip circumference and waist-hip ratio (n F=15.580, 4.679, 6.186, 3.553, 3.153, 2.689, 5.170, 3.114, 3.535, all n P<0.05). The VFA of the normal proteinuria group, microalbuminuria group, massive proteinuria group and renal failure group were (102.25±37.09)cmn 2, (104.12±40.93)cmn 2, (119.63±48.82)cmn 2, (110.54±41.58)cmn 2, respectively, and the BAPWV were (1 546.97±330.18)cm/s, (1 595.52 ±381.27)cm/s, (1 459.63±285.61)cm/s, (1 703.89±318.64)cm/s, the differences were statistically significant among the four groups(n F=3.344, 4.020, all n P<0.05). There were statistically significant differences in alanine aminotransferase, creatinine, uric acid, total cholesterol, red blood cell, hemoglobin, ratio of neutrophils to lymphocytes (NLR) and ratio of platelets to lymphocytes (PLR) among the four groups (n F=3.405, 15.535, 6.552, 2.803, 6.158, 15.580, 3.764, 3.262, all n P<0.05). With VFA as strain, multivariate linear regression analysis showed that waist circumference, BMI, TG and BAPWV were risk factors for VFA.n Conclusion:DN is associated with multiple obesity-related indicators and inflammatory indicators such as NLR, PLR; VFA is associated with BAPWV.