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CD40为48 000的跨膜糖蛋白细胞,CD40L为其配体,分属于TNF-α受体／TNF-α家族成员。树突状细胞(DC)、巨噬细胞、上皮细胞、造血祖细胞以及活化的CD8+T细胞都表达CD40。而CD40L集中表达于活化的T细胞、B细胞和血小板表面。在免疫应答中,CD40与CD40L相互作用是B细胞活化的最重要共刺激信号,并能活化末成熟DC使之具有免疫原性,上调
CD40 is a transmembrane glycoprotein of 48 000. CD40L is its ligand and belongs to the TNF-alpha receptor / TNF-alpha family member. Dendritic cells (DCs), macrophages, epithelial cells, hematopoietic progenitor cells and activated CD8 + T cells express CD40. CD40L is expressed on activated T cells, B cells and platelets. In the immune response, the interaction of CD40 with CD40L is the most important costimulatory signal for B cell activation and activates the mature DC to make it immunogenic, up-regulated