本实验用扫描电镜观察了~(60)Co—r射线8 Gy全身一次照射后第6天小鼠腹腔巨噬细胞的功能变化,以及5-羟色胺(5-HT)对其影响。发现照射后腹腔巨噬细胞形态不一,表面叶状突起变细,巨噬细胞对鸡红细胞的粘附、固定、扑获和鸡红细胞在巨噬细胞内被消化等过程延迟,吞噬现象不活跃。而照射前给予5-HT腹腔注射,可使受照小鼠腹腔巨噬细胞体积变大; In this study, we observed the functional changes of peritoneal macrophages and the effects of 5-hydroxytryptamine (5-HT) on the 6th day after 8 Gy whole body irradiation with ~ (60) Co-r radiation. It was found that the morphology of peritoneal macrophages after irradiation varied, the surface lobes became thinner, macrophages adhered to chicken erythrocytes and fixed, the process of capture and erythrocytes being digested in macrophages was delayed, phagocytosis was not active . The intraperitoneal injection of 5-HT given before irradiation could make the peritoneal macrophages volume of irradiated mice larger;