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目的探讨比较动脉介入治疗联合经皮穿刺消融治疗肝脏肿瘤的临床疗效。方法选择2010年6月至2011年6月本院收治的肝脏肿瘤患者120例,将其随机分为单纯动脉介入治疗组(对照组)和介入治疗联合经皮穿刺消融治疗组(观察组),两组各60例,对照组常规股动脉穿刺,肝动脉注入氟尿嘧啶1.0g,ADM60mg,DDP80mg,HCPT20mg,1次/m,连续治疗3个月;观察组采用介入治疗后1周行微波凝固治疗(MTC),微波治疗后同时行无水酒精注射。疗程结束后观察两组总有效率及QOL、KPS评分改善情况。结果治疗后,观察组总有效率为98.33%,对照组为83.33%,两组差异有统计学意义(P<0.05)。两组治疗后QOL及KPS评分均有改善,与治疗前比较,差异均有统计学意义(P<0.05);且观察组改善较对照组明显(P<0.05)。结论动脉介入治疗联合经皮穿刺消融治疗肝脏肿瘤,疗效显著,患者生活质量明显提高,值得临床推广应用。
Objective To investigate the clinical efficacy of percutaneous interventional ablation combined with percutaneous puncture ablation in the treatment of liver tumors. Methods From June 2010 to June 2011, 120 patients with liver cancer who were treated in our hospital were randomly divided into three groups: the intervention group (intervention group) and the percutaneous intervention group (observation group) 60 cases in each group were treated by conventional femoral artery puncture. The rats in the control group were given fluorouracil 1.0g, ADM60mg, DDP80mg, HCPT20mg, once daily for 3 months. The observation group was treated with microwave coagulation therapy 1 week after interventional therapy MTC), after microwave treatment simultaneously with anhydrous alcohol injection. After the end of treatment, the total effective rate and improvement of QOL and KPS scores were observed. Results After treatment, the total effective rate was 98.33% in the observation group and 83.33% in the control group, with significant difference between the two groups (P <0.05). The scores of QOL and KPS in both groups improved after treatment, which were significantly different from those before treatment (P <0.05). The improvement in observation group was more obvious than that in control group (P <0.05). Conclusion Arterial intervention combined with percutaneous puncture ablation of liver tumors, significant effect, the quality of life of patients was significantly improved, worthy of clinical application.