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通过白碘酚粘堵输卵管的家兔试验,探讨了粘堵输卵管组织的机理。显微镜下观察:注药后,引起输卵管局限性炎症的病理变化。首先炎性细胞浸润、血管扩张充血,三天后,浸润输卵管管壁的全层,并可见炎性渗出物。两周后,炎性细胞逐渐减少,间质组织增生,腺体互相融合,部分管腔开始闭塞,由大量异物肉芽组织充填,炎性细胞消失。六周至十周,输卵管管腔完全闭塞,被大量纤维结缔组织充填,进而胶原化,纤维瘢痕形成。我院于一九七九年开始用中药白芨为粘合剂研究试制成功输卵管粘堵剂“白碘酚”。在临床推广应用的同时进行了以探讨闭塞输卵管机理为目的的动物实验的研究,结果如下。
Through the white lodophenol sticky tubal rabbit test to explore the mechanism of blocking the tubal tissue. Microscopic observation: After injection, causing pathological changes of localized tubal inflammation. First inflammatory cell infiltration, vasodilation and congestion, three days later, infiltrating the full thickness of the tubal wall, and visible inflammatory exudate. Two weeks later, inflammatory cells gradually decreased, interstitial tissue hyperplasia, glands merge with each other, some of the lumen began to occlusion, filled by a large number of foreign body granulation tissue, inflammatory cells disappear. Six weeks to ten weeks, tubal lumen completely occluded, was filled with a large number of fibrous connective tissue, thereby collagen, fibrous scar formation. Our hospital began in 1979 with the Chinese medicine Baizhi as a binder to study the success of tubal blocking agent “white iodophenol.” In clinical application at the same time to explore the mechanism of occluding tubal for animal experiments, the results are as follows.