论文部分内容阅读
目的探讨溃疡性结肠炎(UC)的临床特征及内镜表现。方法总结我院1984年10月至2004年12月经结肠镜检查及病理确诊的UC患者的相关资料,分析其内镜检查结果及临床特点。结果经结肠镜检查确诊的UC患者为802例,占同期结肠镜检查患者总数的4.7%;男女之比为1∶1.1;平均发病年龄为(39.3±13.0)岁,高峰年龄段为30～39岁。UC的发病率呈明显上升趋势。临床主要表现为黏液脓血便、腹泻和腹痛;5%的患者伴有肠外表现(关节炎、眼部疾病及皮疹等)。病变部位以直肠、乙状结肠多见(62%),病情以轻、中度为主(84%)。结肠镜诊断UC的准确率为95%。临床治疗以内科保守治疗为主,总有效率可达95%,药物主要有5!氨基水杨酸(5!ASA)、激素和抗生素等。结论UC的发病率呈明显上升趋势,病变以轻、中度为主,病变大部分局限在左半结肠。结肠镜对UC有较大的诊断价值。肠外表现及并发症较少见,5!ASA和激素治疗总体疗效好,手术率、死亡率和癌变率低。
Objective To investigate the clinical features and endoscopic findings of ulcerative colitis (UC). Methods The data of UC patients diagnosed by colonoscopy and pathology from October 1984 to December 2004 in our hospital were summarized, and the results of endoscopy and clinical features were analyzed. Results The total number of UC patients diagnosed by colonoscopy was 802, accounting for 4.7% of the total number of colonoscopy patients in the same period. The ratio of male to female was 1: 1.1. The average age of onset was (39.3 ± 13.0) years and the peak age was 30-39 year old. The incidence of UC showed a clear upward trend. The main clinical manifestations of mucus pus and blood, diarrhea and abdominal pain; 5% of patients with parenteral manifestations (arthritis, eye diseases and rashes, etc.). Lesions to the rectum, sigmoid colon more common (62%), mild to moderate disease (84%). Colonoscopy diagnosis of UC accuracy of 95%. Clinical treatment of medical conservative treatment, the total effective rate of up to 95%, the drug has 5% aminosalicylic acid (5! ASA), hormones and antibiotics. Conclusions The incidence of UC showed a clear upward trend. The lesions were mainly mild and moderate, and most of the lesions were confined to the left colon. Colonoscopy has a greater diagnostic value of UC. Extraintestinal manifestations and complications are rare, 5 ASA and hormone therapy overall good effect, surgery rate, mortality and cancer rate is low.