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目的评价无创正压通气(NIPPV)治疗慢性阻塞性肺病(COPD)合并呼吸衰竭的临床应用价值。方法回顾性分析COPD并呼吸衰竭122例患者的临床资料,比较使用NIPPV和未使用NIPPV治疗前后动脉血气及临床症状的改善。结果采用NIPPV治疗1d后pH值升高(P<0.05),PaO2明显升高(P<0.01),PaCO2明显降低(P<0.01);未使用NIPPV治疗1d后PaO2升高(P<0.05),治疗3d后PaCO2开始下降(P<0.05)。同时NIPPV治疗组患者心脑并发症和死亡比例明显低于非NIPPV组(P<0.01)。结论NIPPV治疗COPD合并呼吸衰竭,在早期纠正缺氧和CO2潴留,减少心脑并发症,降低死亡率。
Objective To evaluate the clinical value of noninvasive positive pressure ventilation (NIPPV) in the treatment of chronic obstructive pulmonary disease (COPD) complicated with respiratory failure. Methods The clinical data of 122 patients with COPD and respiratory failure were retrospectively analyzed. The arterial blood gases and clinical symptoms were compared before and after treatment with NIPPV and without NIPPV. Results After treatment with NIPPV for 1 day, the PaO2 was significantly increased (P <0.01) and the PaCO2 was significantly decreased (P <0.01) PaCO2 began to decline after 3 days of treatment (P <0.05). At the same time, the proportion of patients with cardiocerebral complications and death in the NIPPV treatment group was significantly lower than that in the non-NIPPV group (P <0.01). Conclusions NIPPV treatment of COPD with respiratory failure, early correction of hypoxia and CO2 retention, reduce cardiovascular complications, reduce mortality.