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目的通过T淋巴细胞亚群的检测,观察慢性浅表性胃炎、萎缩性胃炎、肥厚性胃炎患者免疫系统的变化,从而提供临床诊断与治疗的依据。方法120例慢性胃炎患者,经胃镜检查选出浅表性胃炎、萎缩性胃炎、肥厚性胃炎患者各40例,分别和40例正常人比较T淋巴细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+比值。结果浅表性胃炎和对照组比,有显著性差异(P<0.05);萎缩性胃炎和对照组比,有非常显著性差异(P<0.01);肥厚性胃炎和对照组比,CD3、CD4值有非常显著性差异(P<0.01),CD8、CD4/CD8比值有差异(P<0.05)。结论检测结果表明,浅表性胃炎、萎缩性胃炎、肥厚性胃炎患者的T淋巴细胞亚群和正常人比均有差异,这表明慢性胃炎发病和机体免疫功能有关。在治疗慢性胃炎的过程中,辅以提高免疫功能的治疗方法对慢性胃炎的治疗效果有积极的作用。
Objective To detect the changes of immune system in patients with chronic superficial gastritis, atrophic gastritis and hypertrophic gastritis through the detection of T lymphocyte subsets, so as to provide the basis for clinical diagnosis and treatment. Methods A total of 120 patients with chronic gastritis were enrolled in this study. Forty patients with superficial gastritis, atrophic gastritis and hypertrophic gastritis were selected by gastroscopy. T lymphocyte subsets CD3 +, CD4 +, CD8 +, CD4 + / CD8 + ratio. Results There was a significant difference between the superficial gastritis and the control group (P <0.05). There was a significant difference between the atrophic gastritis group and the control group (P <0.01). The ratio of CD3 and CD4 There was a significant difference between the two groups (P <0.01). There was a significant difference in the ratio of CD8 and CD4 / CD8 (P <0.05). Conclusions The test results show that there are differences in T lymphocyte subsets and normal persons in patients with superficial gastritis, atrophic gastritis and hypertrophic gastritis, which indicates that the pathogenesis of chronic gastritis is related to immune function. In the treatment of chronic gastritis in the process, supplemented by immune function to improve the therapeutic effect of chronic gastritis have a positive effect.