论文部分内容阅读
泛美卫生局(WHO泛美地区组织)召开有21个国家37名临床医师和结核病防治专家参加的会议,作出下列结论。一、现代结核病化疗的进展 (一)短程化疗的细菌学基础结核病化疗的目的是对病灶快速而完全地灭菌,避免产生耐药菌而引起的失败,防止复发。尽管结核野生菌中变异耐药细菌的百分比很高,这些耐药菌也容易通过有效的对细菌敏感的联合用药来克服。为了迅速和完全地灭菌,药物的选择必须根据它们对存在于病灶菌群中各类细菌的特殊活性:空洞壁内分裂活跃的细菌;巨噬细胞内缓慢分裂的细菌;以及块状干酪病灶中间断生长的“顽固菌”。药物可能是杀菌剂或抑菌剂,但在某些条件下可能完全无效。肺空洞壁内大量分裂活跃的细菌,当pH
The Pan American Health Authority (WHO Pan-American Organization) convened a meeting of 37 clinicians and tuberculosis specialists from 21 countries and concluded the following. First, the progress of modern tuberculosis chemotherapy (A) Basis of bacteriology of short-course chemotherapy The purpose of chemotherapy is rapid and complete sterilization of the lesion, to avoid failure caused by drug-resistant bacteria to prevent recurrence. Despite the high percentage of mutant-resistant bacteria in tuberculosis, these resistant bacteria are easily overcome by effective bacterial-sensitive combinations. In order to be sterilized quickly and completely, the choice of drug must be based on their specific activity on various types of bacteria present in the flora of the lesion: bacteria that are actively dividing in the hollow wall; bacteria that divide slowly in macrophages; and mass cheese lesions In the intermittent growth of “stubborn bacteria.” Drugs may be fungicides or bacteriostats, but may be completely ineffective under certain conditions. A large number of bacteria in the lung cavity walls divide actively when pH