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为探讨大鼠急性出血坏死性胰腺炎（ＡＨＮＰ）胰腺组织结构改变与内毒素血症的关系及纳屈酮的治疗作用，用５％牛磺胆酸钠逆行胰胆管注射制成ＡＨＮＰ模型。取Ｗｉｓｔａｒ大鼠１１０只随机分为假手术组（ｎ＝２０）、ＡＨＮＰ组（ｎ＝４５）、纳屈酮治疗组（ｎ＝４５），分别于术后６、１２、２４小时称取胰腺重量，观察ＡＨＮＰ大鼠胰腺组织结构改变，同时测定其血浆淀粉酶和内毒素水平，并与假手术组比较。结果：与假手术组比较，ＡＨＮＰ组血浆淀粉酶、内毒素及胰腺系数升高，在光镜及电镜下可见胰腺损害随时间延长而加重。纳屈酮治疗组与ＡＨＮＰ组相比，其血浆淀粉酶、内毒素及胰腺系数下降，而且胰腺损害减轻。本实验结果提示：ＡＨＮＰ引发内毒素血症，纳屈酮可通过改善胰腺缺血性损害而降低血浆内毒素，延长大鼠生存时间及降低病死率
AHNP model was made by injecting 5% sodium taurocholate into pancreatic duct in order to investigate the relationship between pancreatic tissue structure changes and endotoxemia in rats with acute hemorrhagic necrotizing pancreatitis (AHNP) and the therapeutic effect of naltrexone. 110 Wistar rats were randomly divided into sham operation group (n = 20), AHNP group (n = 45) and naltrexone treatment group (n = 45). Pancreas was weighed at 6, 12 and 24 hours after operation The changes of pancreatic tissue structure in AHNP rats were observed. The levels of amylase and endotoxin in plasma were measured and compared with the sham operation group. Results: Compared with the sham-operation group, the plasma amylase, endotoxin and pancreatic coefficient increased in AHNP group. Pancreatic damage was aggravated with time by light microscope and electron microscope. Naltrexone treatment group compared with AHNP group, the plasma amylase, endotoxin and pancreatic coefficient decreased, and reduce pancreatic damage. The results suggest that: AHNP-induced endotoxemia, naltrexone can reduce plasma endotoxin by improving pancreatic ischemic damage, prolong survival and reduce mortality in rats