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目的:分析我国大陆亚急性硬化性全脑炎(SSPE)病例的临床资料,探讨诊断和治疗中应注意的问题。方法检索中国学术期刊全文数据库,收集1978年1月以来报道的SSPE病例45例,分析其流行病学特征,发病特点,临床表现、诊断、治疗及转归。结果我国大陆报道的病例以儿童青少年居多,男性多于女性。发病前多有麻疹病毒感染史。典型的临床表现为神经系统慢性退行性病变,智力损害、肌肉的痉挛和癫痫发作。诊断主要根据临床表现,血液及脑脊液检查,脑电图(EEG),磁共振(MRI)及CT。治疗上主要是对症处理,缺乏特效药。结论SSPE在我国大陆发病率1～4/百万死亡率为82.24%。应加强对SSPE的研究,增强预防,诊断和治疗SSPE的能力。
Objective: To analyze the clinical data of subacute sclerosing panencephalitis (SSPE) in mainland China and to discuss the problems that should be paid attention to in diagnosis and treatment. Methods The full-text database of Chinese academic journals was searched and 45 SSPE cases reported since January 1978 were collected for analysis of their epidemiological characteristics, clinical features, clinical manifestations, diagnosis, treatment and prognosis. Results The reported cases in mainland China were mostly children and adolescents, with more males than females. Before the onset of more history of measles virus infection. Typical clinical manifestations are chronic degenerative neurological disease, impaired intelligence, muscle spasms and seizures. The diagnosis is mainly based on clinical manifestations, blood and cerebrospinal fluid tests, electroencephalography (EEG), magnetic resonance imaging (MRI) and CT. Treatment is mainly symptomatic treatment, the lack of cure. Conclusion The incidence of SSPE in mainland China is 1 ~ 4 / million mortality rate is 82.24%. Research on SSPE should be strengthened to enhance the ability to prevent, diagnose and treat SSPE.