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白桦酸是一种来源于天然植物的羽扇豆烷型五环三萜类产物,具有一定的抗肿瘤活性。近年来,为了增强白桦酸的水溶性以及抗肿瘤活性,研究人员对其结构进行了大量的修饰与改造,获得了一些具有潜在抗肿瘤研究价值的白桦酸衍生物。综述了近3年来白桦酸衍生物的抗癌研究进展,以期为白桦酸的结构修饰提供帮助。
Betulinic acid is a lupine pentacyclic triterpene product derived from natural plant and has certain anti-tumor activity. In recent years, in order to enhance the water solubility and anti-tumor activity of betulinic acid, researchers have carried out a large number of modifications and alterations on its structure and obtained some derivatives of betulinic acid with potential anti-tumor research value. In this paper, the progress of research on anti-cancer of betulinic acid derivatives in recent 3 years is reviewed in order to provide help for the structural modification of betulinic acid.