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研究了一系列铜盐催化的氧化环己烯与苯基氯化镁的开环加成反应。发现 Cu(OTf) 2 [三氟甲磺酸铜 ( ) ]为催化剂时 ,反应能够以 95 %的产率得到反式 - 2 -苯基环己醇。应用了多种代表性的手性双齿配体与 Cu(OTf) 2 形成的配合物 ,催化氧化环己烯与苯基氯化镁的开环加成反应 ,得到很低的对映选择性。根据实验的结果建议了反应的催化循环机理。
A series of copper salt-catalyzed ring-opening addition reactions of cyclohexene oxide with phenylmagnesium chloride were studied. When Cu (OTf) 2 [copper triflate] was found to be a catalyst, the reaction gave trans-2-phenylcyclohexanol in 95% yield. A variety of representative complexes of chiral bidentate ligands with Cu (OTf) 2 were used to catalyze the ring-opening addition reaction of cyclohexene with phenylmagnesium chloride to obtain a very low enantioselectivity. Based on the experimental results, the catalytic cycling mechanism of the reaction is suggested.