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目的 探讨黏附因子ＣＤ４４ｓ和ＣＤ４４ｖ６的表达与胃癌生物学行为的关系。方法 应用流式细胞术对５８例胃癌及４０例胃良性病变的新鲜标本检测ＣＤ４４ｓ和ＣＤ４４ｖ６，并应用免疫组化测定ＰＣＮＡＬ１。结果 胃癌组ＣＤ４４ｓ的阳性率（６２．１％，３６／５８）明显高于良性病变组（２７．５％，１１／４０，Ｐ＜０．０１），且与ＰＣＮＡＬＩ（Ｐ＜０．０５）有关。胃癌组ＣＤ４４ｖ６的阳性率（５８．６％，３４／５８）高于良性病变组（３２．５％，１３／４０，Ｐ＜０．０５），且与肿瘤部位（Ｐ＜０．０５）、淋巴结转移（Ｐ＜０．０５）及ＰＣＮＡＬＩ（Ｐ＜０．０５）有关。ＣＤ４４ｓ与ＣＤ４４ｖ６表达在胃良性病变组（Ｒｓ＝０．５９，Ｐ＜０．０１）及胃癌组中（Ｒｓ＝０．２９，Ｐ＜０．０５）存在相关性。结论 ＣＤ４４ｓ和ＣＤ４４ｖ６之间存在相关性并在胃癌中表达增强并和增殖活性有关，ＣＤ４４ｖ６与肿瘤部位及淋巴结转移有关。
Objective To investigate the relationship between the expression of adhesion molecules CD44s and CD44v6 and the biological behavior of gastric cancer. Methods Flow cytometry was used to detect CD44s and CD44v6 in fresh specimens of 58 cases of gastric cancer and 40 cases of benign gastric lesions. PCNAL1 was detected by immunohistochemistry. Results The positive rate of CD44s in gastric cancer group (62.1%, 36/58) was significantly higher than that in benign disease group (27.5%, 11/40, P<0.01), and it was also associated with PCNALI (P<0.05). related. The positive rate of CD44v6 in gastric cancer group (58.6%, 34/58) was higher than that in benign disease group (32.5%, 13/40, P<0.05), and with the tumor site (P<0.05). Lymph node metastasis (P<0.05) and PCNALI (P<0.05) were related. There was a correlation between CD44s and CD44v6 expression in benign lesions (Rs=0.59, P<0.01) and gastric cancer (Rs=0.29, P<0.05). Conclusions There is a correlation between CD44s and CD44v6 and the expression is increased in gastric cancer and is related to the proliferation activity. CD44v6 is related to tumor site and lymph node metastasis.