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愈心痛胶囊主要由红参、三七、延胡索等药物组成,具有活血化瘀,强心止痛之效,用于治疗冠心病心绞痛,心肌梗塞等疾患。内皮素是迄今所知体内作用最强的血管收缩因子,参与血栓形成、心肌梗死、脑血管意外等多种疾病的发病机制。为进一步阐明血瘀证本质,探讨血浆内皮素与血瘀证的关系和愈心痛胶囊对血瘀证的影响,本实验以结扎犬冠状动脉左前降支中段的方法,造成急性实验性犬心肌缺血模型,以诱导血栓形成及血液流变性的异常状态,形成中医血瘀证,并动态观察了给药前后血浆内皮素含量和各项血液流变学指标的变化。结果报告如下。
Yuxintong capsules are mainly composed of red ginseng, Panax notoginseng, and Corydalis yanhusuo. They have the effects of promoting blood circulation, removing blood stasis, and relieving pain. They are used to treat coronary heart disease such as angina pectoris and myocardial infarction. Endothelin is the most potent vasoconstrictor known to date and is involved in the pathogenesis of various diseases such as thrombosis, myocardial infarction, and cerebrovascular accidents. In order to further clarify the nature of blood stasis syndrome, to explore the relationship between plasma endothelin and blood stasis syndrome and Yuxintong capsule effect on blood stasis syndrome, this experiment to ligated the middle of the left anterior descending coronary artery canine acute experimental canine myocardial infarction Blood model to induce thrombosis and blood rheological abnormalities, the formation of traditional Chinese medicine blood stasis syndrome, and dynamic observation before and after administration of plasma endothelin levels and changes in various hemorheological parameters. The results are reported below.