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目的研究单指标中位数倍数(multiple of median,Mo M)值阈值和风险灰区对血清学产前筛查效能的影响。方法对石家庄市妇幼保健院2012年1月至2013年4月105 899例孕妇孕中期唐氏综合征筛查结果进行甲胎蛋白(alphafetoprotein,AFP)、人绒毛膜促性腺激素(human chorionic gonadotropin,HCG)和游离雌三醇(unconjugated estriol,u E3)的Mo M值百分位数分析,21-三体风险灰区分析。结果最适合本实验室的单指标Mo M值阈值是HCG Mo M 2.70和u E3Mo M 0.50,风险灰区设置的效率偏低。结论实验室在考虑设置单Mo M值阈值和灰区时,应在经验的基础上,再回顾历史数据,设置合理的阈值和灰区。
Objective To investigate the effect of multiple indicators of median (Mo M) threshold and risk gray zone on the prenatal screening efficacy of serology. Methods The screening results of Down syndrome in 105 899 pregnant women during the second trimester of pregnant women from January 2012 to April 2013 in Shijiazhuang MCH hospital were analyzed with alphafetoprotein (AFP), human chorionic gonadotropin HCG) and unconjugated estriol (u E3) Mo M value percentile analysis, 21-trisomy risk gray zone analysis. Results The most suitable MoM thresholds for our laboratory were HCG Mo M 2.70 and u E3Mo M 0.50, and the efficiency of setting the risk gray zone was low. Conclusions When considering the setting of single Mo M thresholds and gray areas, laboratories should review historical data and set reasonable thresholds and gray areas on the basis of experience.