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通过腹腔注射异丙肾上腺素及进行游泳刺激复制大鼠“气虚血瘀证”心肌缺血模型,观察不同剂量人参汤粗提液对正常及“气虚血瘀证”心肌缺血大鼠血清心肌酶活性[乳酸脱氢酶(LDH)、肌酸激酶(CK)]、热休克蛋白(HSP70)表达以及心肌组织病理切片等指标影响。为其临床应用于气虚血瘀型心绞痛的治疗提供依据。结果表明人参汤粗提液对气虚血瘀证大鼠缺血心肌有明显的改善作用。
Through islet injection of isoprenaline and swimming stimulation to copy the rat model of myocardial ischemia with qi deficiency and blood stasis, we observed the effect of different doses of crude extract of ginseng decoction on normal and myocardial ischemia of Qi deficiency and blood stasis syndrome (LDH), creatine kinase (CK)], the expression of heat shock protein (HSP70) and myocardial histopathological parameters in serum of rats. For its clinical application in the treatment of Qi-deficiency and blood-stasis type angina. The results showed that the crude extract of ginseng decoction on ischemic myocardium in rats with qi deficiency and blood stasis had a significant improvement.