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研究表明,恶性肿瘤患者都存在不同程度的免疫功能紊乱。机体的抗肿瘤免疫反应主要是指白细胞免疫系统的细胞免疫反应。1981年Siegel等提出红细胞具有多种免疫功能,也是机体免疫系统的重要组成部分,而红细胞表面的C3b受体(C3bR,也称第一补体受体,CR_1是红细胞进行免疫粘附,抗原递呈及裂解补体C3b的关键部位,是其发挥免疫功能的物质基础。1997年我们检测了30例肺癌患者外周血的红细胞膜C3bR花环形成率(RBCC3bRR),红细胞膜吸附免疫复合物花环率(RBC-ICR)和循环中免疫复合物花环率含量(CIC),以探讨肺癌患者的红细胞免疫状态及其临床意义。
Studies have shown that patients with malignant tumors have varying degrees of immune dysfunction. The body’s anti-tumor immune response mainly refers to the cellular immune response of the leukocyte immune system. In 1981, Siegel et al. proposed that red blood cells have multiple immune functions and are an important part of the body’s immune system. The C3b receptor on the surface of red blood cells (C3bR, also called the first complement receptor, and CR_1 are red blood cells for immunoadhesion, antigen presentation. The key part of lytic complement C3b is the material basis for its immune function.In 1997, we detected the erythrocyte membrane C3bR garland formation rate (RBCC3bRR) in peripheral blood of 30 patients with lung cancer, and the red cell membrane adsorbed immune complex rosette rate (RBC- ICR) and circulating immune complex rosette content (CIC) were used to investigate the red blood cell immune status and its clinical significance in patients with lung cancer.