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利用人卵巢癌细胞株，在确定Ｃ－ｅｒｂＢ－２扩增和过表达及Ｃ－ｅｒｂＢ２正常拷贝和低表达的基础上对Ｃ－ｅｒｂＢ－２扩增及表达与ＴＮＦ和ＬＡＫ杀伤活性的关系进行研究，并以非特异性杀伤物Ｈ２Ｏ２为对照。结果表明：Ｃ－ｅｒｂＢ－２扩增及过表达可明显抑制ＴＮＦ和ＬＡＫ的杀伤活性（Ｐ＜０．０５），但对Ｈ２Ｏ２的杀伤活性无显著影响。提示临床上部分卵巢癌患者用ＴＮＦ和ＬＡＫ治疗的疗效低或无反应性与Ｃ－ｅｒｂＢ－２的扩增及过表达有关。
Using human ovarian cancer cell lines, the relationship between C-erbB-2 amplification and TNF and LAK killing activity was determined on the basis of confirming C-erbB-2 amplification and overexpression and normal copy and low expression of C-erbB2 Study, and non-specific killing H2O2 as a control. The results showed that C-erbB-2 expansion and overexpression could significantly inhibit the cytotoxic activity of TNF and LAK (P <0.05), but had no significant effect on the cytotoxic activity of H2O2. Prompt clinical ovarian cancer patients with TNF and LAK treatment of low or no response with the C-erbB-2 amplification and overexpression.