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研制了一种可探测极微弱细胞荧光图象的高灵敏度荧光显微镜，在仪器中使用了一个高质量的亮度增益为５０，０００的象增强器对细胞的荧光图象进行光能量放大，因而这种荧光显微镜可探测到普通荧光显微镜不能观察的微弱荧光图象。由于仪器中光源的输出强度很小，避免了长时间观察对活细胞的光损伤，并可观察到荧光效率低的荧光物质的分布图象。探测系统中用计算机采集图象数据，同时对数据进行必要处理，以提高图象的质量。这种高灵敏度的荧光显微镜可用于分析细胞中荧光物质的分布，以及细胞动态生理过程的研究。使用此仪器已直接观察到光敏竹红菌甲素在Ｈｅｌａ细胞（人体宫颈癌细胞）中的分布，细胞受光照射后的光损伤现象及加入三种细胞保护剂后获得不同程度保护的细胞状态。
A highly sensitive fluorescence microscope was developed for detecting fluorescent images of extremely feeble cells using a high-quality image intensifier with a brightness gain of 50,000 to amplify the fluorescence energy of the cells so that Fluorescence microscopy detects weak fluorescence images that can not be observed with ordinary fluorescence microscopy. Since the output intensity of the light source in the instrument is very small, it is possible to avoid observing light damage to the living cells for a long time and to observe the distribution of the fluorescent substance with low fluorescence efficiency. Detection system using a computer to capture image data, while the data necessary to deal with to improve the quality of the image. This highly sensitive fluorescence microscope can be used to analyze the distribution of fluorescent substances in cells, as well as studies on the dynamic physiological processes of cells. Using this instrument, the distribution of Hypocrellin A in Hela cells (human cervical cancer cells), photodamage after exposure to light, and cell status with different degrees of protection after adding three kinds of cytoprotectants have been directly observed.