论文部分内容阅读
目的探讨鼠双微粒体基因-2(murine double minute,MDM-2)蛋白在胃腺癌组织中表达的临床病理学意义。方法应用免疫组织化学染色法检测MDM-2蛋白在82例胃腺癌患者的胃腺癌组织及癌旁正常组织中的表达情况,结合临床资料分析其病理学意义。结果胃腺癌组织中MDM-2蛋白阳性表达率(62.19%)高于癌旁正常组织(25.61%)(P<0.05);其中低分化胃腺癌MDM-2阳性表达率(83.33%)高于中、高分化胃腺癌(60.94%),有淋巴结转移患者MDM-2阳性表达率(80.95%)高于无淋巴结转移者(55.74%),差异均有统计学意义(P<0.05)。结论 MDM-2蛋白异常表达对胃腺癌临床诊断、预后判断有重要作用。
Objective To investigate the clinicopathological significance of murine double minute (MDM-2) protein expression in gastric adenocarcinoma. Methods Immunohistochemical staining was used to detect the expression of MDM-2 protein in 82 cases of gastric adenocarcinoma and adjacent normal tissues. The pathological significance was analyzed based on clinical data. Results The positive rate of MDM-2 protein in gastric adenocarcinoma (62.19%) was higher than that in adjacent normal tissues (25.61%) (P <0.05). The positive rate of MDM-2 in poorly differentiated gastric adenocarcinoma was higher than that in moderate (60.94%). The positive rate of MDM-2 expression in patients with lymph node metastasis (80.95%) was higher than that in patients without lymph node metastasis (55.74%), the difference was statistically significant (P <0.05). Conclusion The abnormal expression of MDM-2 protein plays an important role in the clinical diagnosis and prognosis of gastric adenocarcinoma.