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目的观察对比以法莫替丁为主的四联疗法根除幽门螺杆菌(Hp)的治疗效果。方法选择258患者,使用双盲法随机分为法莫替丁组和洛赛克组,法莫替丁组加用甲硝唑、阿莫西林及果胶铋组成四联疗法;洛赛克组用甲硝唑、阿莫西林组成三联疗法,均进行为期7d的治疗,通过对临床消化道症状的消失率评定效果,停用所有药物1月后复查胃镜,观察病变愈合情况及Hp根除情况以评定治疗效果。结果两组治疗7d后消化道症状均明显改变,法莫替丁组和洛赛组分别为87.9%和90.3%(P>0.05),病变愈合情况均为100%(P>0.05)。Hp根除情况,法莫替丁组和洛赛克组总Hp根除率分别为89.6和91.3%(P>0.05)。结论以法莫替丁为主的四联疗法根除Hp疗效肯定,且价格便宜,服药方便,无明显副作用,值得在临床上广泛推广使用。
Objective To observe and compare the efficacy of tetrad by famotidine in the eradication of Helicobacter pylori (Hp). Methods 258 patients were randomly divided into famotidine group and Losec group using double-blind method. Four groups were treated with famotidine, metronidazole, amoxicillin and pectin bismuth. Losec group With metronidazole, amoxicillin triple therapy, were treated for a period of 7d, through the disappearance of clinical gastrointestinal symptoms assessment results, disable all drugs after 1 month review of gastroscopy to observe the lesion healing and Hp eradication Assessment of treatment. Results The symptoms of digestive tract in both groups were significantly changed after treatment for 7 days. The famotidine group and loxar were 87.9% and 90.3% respectively (P> 0.05), and the lesion healing was 100% (P> 0.05). Hp eradication, famotidine group and Losec group total Hp eradication rates were 89.6 and 91.3% (P> 0.05). Conclusions Tetradotherapy dominated by famotidine is effective in eradicating Hp and is cheap and convenient to take. It has no obvious side effects and should be widely used clinically.