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目的分析人乳头状瘤病毒(HPV)感染与宫颈鳞癌临床病理因素的相关性,为临床诊断宫颈鳞癌提供理论指导与依据。方法选取2013年1月-2015年10月在医院就诊的宫颈鳞癌患者90例为研究对象,患者均行广泛性子宫切除及盆腔淋巴结切除,分析患者的HPV感染情况、液基细胞学(TCT)检查结果、分化程度、肿瘤分期情况、肿瘤直径、间质浸润深度及淋巴结转移情况;采用SPSS16.0软件进行统计分析。结果 90例患者中HPV阳性率为100.0%,其中多重感染23例占25.6%,单一感染67例占74.4%,多重感染HPV类型主要以HPV33、16、18、52为主,单一感染其HPV类型主要以HPV18、16、45、58为主;TCT检测81例阳性患者,阳性率为90.0%,其中非典型鳞状上皮细胞(ASC-H)11例,鳞癌+腺癌(SCC+AC)18例,低度鳞状上皮内病变(LSIL)25例,高度鳞状上皮内病变(HSIL18)例,意义不明的非典型鳞状细胞及非典型腺细胞(ASCUS+AGC)9例;HPV检测阳性率随着宫颈癌的病变进展而相应提高;宫颈鳞癌患者HPV单一感染比多重感染其肿瘤分期(FIGO)晚,且更容易发展为宫颈癌;不同HPV感染方式的临床肿瘤分期差异有统计学意义(P<0.05)。结论高危型HPV检测阳性率与宫颈癌的病变进展密切相关,可影响宫颈鳞癌患者临床表现及相关复发因素。
Objective To analyze the correlation between human papillomavirus (HPV) infection and clinicopathological factors of cervical squamous cell carcinoma, and to provide theoretical guidance and basis for clinical diagnosis of cervical squamous cell carcinoma. Methods Ninety patients with cervical squamous cell carcinoma who visited the hospital from January 2013 to October 2015 were enrolled in this study. The patients underwent extensive hysterectomy and pelvic lymphadenectomy. The HPV infection status, ) Examination results, the degree of differentiation, tumor staging, tumor diameter, depth of interstitial infiltration and lymph node metastasis; using SPSS16.0 software for statistical analysis. Results The positive rate of HPV in 90 patients was 100.0%, of which 23 cases were multiple infections (25.6%) and 67 cases (74.4%). The HPV types of multiple infections were mainly HPV33, HPV16, HPV16, HPV16 Mainly HPV18,16,45,58 TCS test positive in 81 patients, the positive rate was 90.0%, of which 11 cases of atypical squamous epithelial cells (ASC-H), squamous cell carcinoma + adenocarcinoma (SCC + AC) 18 cases, low grade squamous intraepithelial lesion (LSIL) 25 cases, high grade squamous intraepithelial lesion (HSIL18) cases, unknown atypical squamous cells and atypical glandular cells (ASCUS + AGC) in 9 cases; HPV test positive Rate of cervical cancer increased with the progress of cervical cancer; cervical squamous cell carcinoma of patients with single HPV infection than the multiple infection of the tumor staging (FIGO) late, and more likely to develop into cervical cancer; different HPV infection clinical staging differences were statistically Significance (P <0.05). Conclusion The positive rate of high-risk HPV testing is closely related to the progression of cervical cancer, which may affect the clinical manifestations and relapse factors of patients with cervical squamous cell carcinoma.