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目的探讨ICU院内败血症感染的临床特点、危险因素及其预防措施。方法对我科2007～2010年医院感染败血症患者相关临床资料进行回顾性分析。结果 46例败血症血微生物培养共获得真菌菌株48株,念珠菌是主要病原体(86.4%);入侵途径以中心静脉导管为最多(35.6%);总病死率58.6%,为同期ICU病死率的8.6倍;多脏器功能衰竭与感染性休克是预后不良的先兆因素。结论真菌感染已成为ICU内危重病患者死亡的重要原因。减少侵袭性操作、合理使用抗生素是降低医院感染败血症的主要措施。
Objective To investigate the clinical features, risk factors and preventive measures of sepsis inpatients in ICU. Methods The clinical data of patients with nosocomial sepsis in our department from 2007 to 2010 were analyzed retrospectively. Results Forty-eight strains of fungi were obtained from blood culture of 46 sepsis patients. Candida was the main pathogen (86.4%). The most common central venous catheter was invasion (35.6%). The overall mortality rate was 58.6% Times; multiple organ failure and septic shock are prognostic factors of poor prognosis. Conclusion Fungal infections have become an important cause of death in critically ill patients in the ICU. Reduce invasive operations, rational use of antibiotics is to reduce the main measures of nosocomial sepsis.