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新生霉素(Novobiocin)和库马霉素(Coumermycin)能抑制DNA螺旋中的B亚单位,呈现出可以矫治抗生素耐药质粒。喹诺酮类抗生素能抑制DNA螺旋中的A亚单位,但未阐明能否矫治抗生素耐药质粒。由此,作者应用喹诺酮类的10种抗生素和库马霉素、新生霉素观察对大肠杆菌、枯草杆菌和金葡菌的各种耐药质粒的消除作用。一般认为喹诺酮对大肠杆菌和金葡菌的抗菌活性比萘啶酸,新生霉素和库马霉素更强。比较实验用7种质粒进行观察,结果上述抗生素对质粒R_1,pPL_(603)和pUB_(110)没有影响,但能消除pORF_2质粒。新生霉素,库马霉素和10个喹诺酮类抗生素在亚抑菌浓度下处理后所呈现的矫治率分别为:氟啶酸
Novobiocin and Coumermycin inhibit the B subunit in the DNA helix and present an antibiotic-resistant plasmid. Quinolyn antibiotics can inhibit the A subunit in the DNA helix, but did not clarify whether antibiotic resistant plasmids could be treated. Thus, the authors applied quinolones 10 kinds of antibiotics and library fumaricin, novobiocin observed on Escherichia coli, Bacillus subtilis and Staphylococcus aureus eliminate the role of a variety of resistant plasmids. Quinolones are generally considered to be more potent against nosocomial and staphylococcus aureus than nalidixic acid, novobiocin, and kreptomycin. Seven plasmids were compared in the experiments. As a result, the above antibiotics did not affect the plasmids R_1, pPL_ (603) and pUB_ (110), but eliminated the pORF_2 plasmid. The rates of treatment of noradrenomycin, kuramycin and 10 quinolone antibiotics after sub-lethal concentration were as follows: