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目的分析成人病毒性乙型肝炎(乙肝)疫苗(HepB)免疫失败的行为危险因素。方法对62名免后乙肝病毒表面抗体(抗-HBs)几何浓度(GMC)<10 mIU/ml的免疫失败者与对照组以年龄、性别、职业为配对条件,1∶1对比调查吸烟、饮酒、拔牙和手术史,计算OR、95%可信限和P值。结果免疫失败组吸烟率高于对照组,差异有统计学意义(P<0.05),而饮酒、拔牙和手术史两组间比较差异均无统计学意义。结论吸烟是HepB免疫失败的主要危险因素。
Objective To analyze the behavioral risk factors for failure of Hepatitis B virus (HepB) vaccine in adults. Methods Sixty-two immunocompromised donors with a GMC of less than 10 mIU / ml after immunization with hepatitis B virus (anti-HBs) were compared with control group on the basis of age, sex and occupation, , Tooth extraction and surgery history, calculated OR, 95% confidence limits and P values. Results The rate of smoking in the immunocompromised group was higher than that in the control group (P <0.05), but there was no significant difference between the two groups in alcohol consumption, tooth extraction and operation history. Conclusion Smoking is the main risk factor for HepB immune failure.