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四氧嘧啶致SD大白鼠糖尿病的过程中,首先引起体内多种组织器官广泛发生脂类过氧化作用。脂类过氧化物分解产生一些醛类物质,故血清、胰腺、肝和肾组织中TBA反应物(主要成分为丙二醛)含量升高;生成的其它醛类物质与蛋白质结合形成的水溶性荧光物质含量亦增多。抗氧化剂维生素E的抗脂类过氧化作用对机体起保护作用;而维生素C在大量氧化剂四氧嘧啶存在的条件下起氧化强化剂的作用,并使机体对维生素E的消耗增多。
Alloxan induced SD rats with diabetes, the first cause a wide range of tissues and organs of the body lipid peroxidation. Lipid peroxides decompose to produce some aldehydes, so serum, pancreatic, liver and kidney tissue TBA reactant (the main component of malondialdehyde) content increased; other aldehydes and proteins formed by the formation of water-soluble Fluorescent substances also increased. Antioxidant vitamin E lipid-lipid peroxidation play a protective role on the body; and vitamin C in the presence of a large number of oxidants alloxan play the role of oxidative enhancer, and the body’s consumption of vitamin E increased.