【摘 要】
：
Several models of experimental ulcerative colitis have been reported previously. However, none of these models showed the optimum characteristics. Although dext
【机 构】
：
Department of Gastroenterology,Lab of Digestive Disease Clinical Institute
论文部分内容阅读
Several models of experimental ulcerative colitis have been reported previously. However, none of these models showed the optimum characteristics. Although dextran sulfate sodium-induced colitis results in inflammation resembling ulcerative colitis, an obvious obstacle is that dextran sulfate sodium is very expensive. The aim of this study was to develop an inexpensive model of colitis in rats. Sprague-Dawley rats were treated with 2% dextran sulfate sodium in drinking water for 3 d followed by an intracolonic administration of 30% ethanol. The administration of 2% dextran sulfate sodium followed by 30% ethanol induced significant weight loss, diarrhea and hematochezia in rats. Severe ulceration and inflammation of the distal part of rat colon were developed rapidly. Histological examination showed increased infiltration of polymorphonuclear leukocytes,lymphocytes and existence of cryptic abscesses and dysplasia. The model induced by dextran sulfate sodium at lower concentration followed by 30% ethanol is characterized by a clinical course, localization of the lesions and histopathological features similar to human ulcerative colitis and fulfills the criteria set out at the beginning of this study.
其他文献
选用16个玉米杂交种为材料,对各试验杂交种的产量和主要农艺性状进行调查及相关分析,结果表明,在南疆春播条件下,玉米杂交种的穗粗、株高、穗长、出籽率是影响产量的主要因素
在多年冻土区修建铁路站场路基,打破了原来天然地表与外界的热力平衡,地下温度场将重新分布。根据此特征可以推断多年冻土的发展演化趋势以及评定路基的稳定状况,结合实际监
目的 回顾分析海绵状血管瘤CT、MRI表现,总结术前CT、MRI对海绵状血管瘤眼眶内粘连程度预测价值.方法 收集97例经病理证实的海绵状血管瘤病例,均行CT水平加冠状扫描,MRI水平
目的 评价内镜下金属支架引流术在近段结肠癌急性肠梗阻中的应用价值.方法 2004年9月至2010年6月中山医院内镜中心共81例近段结肠癌急性肠梗阻被纳入了研究,患者中男47例,女3
目的 探讨煤矿在职接尘工人煤工尘肺病发病特点,为指导煤工尘肺防治工作提供依据.方法 选择某矿业集团坚持定期健康检查、资料保存完整的3个煤矿,以调查前一年进行过尘肺病检
心肌炎可由多种致病因素引起,病毒感染是常见原因。其临床表现和常规辅助检查缺乏特征性,心内膜心肌活检可确诊,但阳性率不高,因而需要综合临床、实验室和影像资料才能得出临
This report gives a better emphasis on the role of targeted effectors (e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone) a
Fragmentation of phosphorylated Tau peptides in matrix assisted laser desorption- /ionization-time of flight-mass spectrometry (MALDI-TOF-MS) has been investiga
Using poor-detonable liquid C8H16/air mixture with low-energy system (total spark energy of 50 mJ) and a new one-step detonation initiation method developed in
In regard to such challenging analysis problems as scientific identification and quality evaluation of Chinese traditional medicine, the electrochemical fingerp