论文部分内容阅读
为探讨氨茶碱在治疗支气管哮喘中的抗炎作用机理，观察哮喘大鼠经氨茶碱治疗后，其血中肿瘤坏死因子α（以下称ＴＮＦα）活性变化及肺组织病理改变。结果为氨茶碱治疗组的ＴＮＦα活性明显低于对照组（Ｐ＜００１），２０ｍｇ／ｋｇ氨茶碱和８０ｍｇ／ｋｇ氨茶碱两治疗组哮喘大鼠血中ＴＮＦα活性无差异（Ｐ＞００５），５ｍｇ／ｋｇ地塞米松治疗大鼠组与两组氨茶碱治疗组比较，地塞米松治疗组的哮喘大鼠血中ＴＮＦα活性明显降低（Ｐ＜００１）。氨茶碱治疗组大鼠肺病理切片可见炎性细胞减少，细、小支气管炎症减轻。氨茶碱具有一定的抗炎作用，且在较低血浆浓度即能显示出来；但其抗炎作用明显低于地塞米松。
In order to investigate the anti-inflammatory mechanism of aminophylline in the treatment of bronchial asthma, we observed the changes of tumor necrosis factor-α (TNFα) in the blood and pathological changes of lung tissue after treatment with aminophylline in asthmatic rats. The results for aminophylline treatment group TNF α activity was significantly lower than the control group (P <0 01), 20 mg / kg aminophylline and 80 mg / kg aminophylline two groups of asthma in rats with TNF α activity No difference (P> 0 05), 5mg / kg dexamethasone treatment rats and aminophylline treatment group compared with two groups, dexamethasone treatment group of asthmatic rats TNF α activity was significantly reduced (P < 0 01). Aminophylline treatment group rats lung inflammatory cells can be seen reduced, small and bronchial inflammation alleviated. Aminophylline has a certain anti-inflammatory effect, and can be displayed at lower plasma concentrations; but its anti-inflammatory effect was significantly lower than dexamethasone.