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目的探讨血清中微量元素硒和糖尿病(Diabetes Mellitus,DM)发病风险间的相关性。方法通过计算机检索中国知网、维普期刊资源整合服务平台、万方和PubMed数据库,查找关于微量元素硒与糖尿病罹患风险的随机对照试验,检索时限从建库起至2016年11月。对纳入文献进行质量评价后,使用Rev Man 5.3和Stata12.0软件进行数据处理与分析。结果最终纳入8篇文献,共2 855例研究对象。经分析后结果显示,DM组人群中血清硒浓度比对照组人群低12.98μg/L[WMD=-12.98,95%CI(-14.47,-11.49),P<0.01],差异有统计学意义,按诊断方法、检测方法进行亚组分组后,整体效应的关联方向和大小未发生改变,提示上述因素不是异质性的来源。结论硒的缺乏会增加糖尿病的罹患风险。
Objective To explore the correlation between the serum risk of selenium and diabetes mellitus (DM). Methods The randomized controlled trials on the risk of trace elemental selenium and diabetes were searched by searching CNKI, VIP database service platform, Wanfang and PubMed database. The search time was from the establishment of the library to November 2016. After evaluating the quality of the included documents, the data were processed and analyzed using RevMan 5.3 and Stata12.0 software. The results eventually included 8 articles, a total of 2 855 subjects. The results showed that the serum selenium concentration in DM group was 12.98μg / L lower than that in control group [WMD = -12.98,95% CI (-14.47, -11.49), P <0.01], the difference was statistically significant, According to the diagnostic method and the testing method, after the subgroups were grouped, the overall direction and size of the overall effect did not change, suggesting that the above factors are not the source of heterogeneity. Conclusions Selenium deficiency increases the risk of diabetes.