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在NaH2PO4-Na2HPO4溶液中,用循环伏安法、差分脉冲伏安法(DSV)和方波伏安法(SWV)在玻碳电极(GCE)上对兰索拉唑进行了电化学研究,发现兰索拉唑在-1.3伏左右有一个明显的阴极还原峰,考察了不同底液及pH、扫描速度、富集时间和静止时间的影响,DSV法线性范围为6.0×10-6～1.0×10-3 mol/L,检出限为5.0×10-7 mol/L;SWV法线性范围为2.0×10-6～2.0×10-3 mol/L,检出限为1.0×10-7 mol/L。并对兰索拉唑的电极反应机理进行了探讨,该方法可用于实际药品测定。
In NaH2PO4-Na2HPO4 solution, Lansoprazole was investigated by cyclic voltammetry, differential pulse voltammetry (DSV) and square wave voltammetry (SWV) on glassy carbon electrode (GCE) Lansoprazole has a significant cathodic reduction peak at -1.3 volts. The effects of different bottom solutions and pH, scanning speed, enrichment time and resting time were investigated. The linear range of DSV was 6.0 × 10-6 ~ 1.0 × The detection limit was 5.0 × 10-7 mol / L. The linear range of SWV was 2.0 × 10-6 ~ 2.0 × 10-3 mol / L with the detection limit of 1.0 × 10-7 mol / L. The mechanism of electrode reaction of lansoprazole was also discussed. This method can be used to determine the actual drug.