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急性淋巴细胞性白血病(ALL)的临床表现、预后以及对于化疗的反应在不同病例中常各不相同。这种变异使学者们认为ALL可能是包括几种形态相似而生物特性不一的疾病。因而近年来学者们试图从ALL的细胞形态及细胞表面标记加以区分,以便采取不同的治疗方案,而达到更好的疗效。 ALL的细胞类型与预后的关系 Mathe′(1971)将ALL按其细胞形态分为4亚型:前原淋型、大原淋型、小原淋型及幼淋型。前原淋细胞分化最差,好些学者将前原淋型归入未分化型细胞白血病。它的体积比其他三型均大,胞浆较多,染色质呈细网状,核仁清晰。前原淋细胞与前原粒细胞(按:Mathe′在粒细胞系、淋巴细胞系及单核细胞系均有前原始细胞的划分)的鉴别主要依据为Auer小体的出现与否,故难于鉴别,尤其在
The clinical manifestations, prognosis, and response to chemotherapy in acute lymphoblastic leukemia (ALL) are often different in different cases. This variation led scholars to think that ALL may include several diseases with similar morphological and biological characteristics. Therefore, in recent years, scholars have tried to distinguish the cell morphology and cell surface markers from ALL in order to adopt different treatment plans to achieve better therapeutic effects. Relationship between cell type and prognosis of ALL Mathe ’(1971) divided ALL into 4 subtypes according to their cell morphology: procollagen, procollagen, prothoracic and lymphoid. Pre-primitive lymphocytic differentiation of the worst, many scholars will be classified as undifferentiated precancerous leukemia leukemia. Its size is larger than the other three types, more cytoplasm, chromatin fine mesh, clear nucleolus. Pre-primitive lymphocytes and pre-primitive granulocytes (Mathe ’in the granulocyte, lymphocytic and mononuclear cell lines are pre-primary cell division) is mainly based on the identification of the presence or absence of Auer bodies, it is difficult to identify, especially in