1964年Jones报告新西兰Maori族的一个家族几代人中胃癌高发病率,他推测其中可能有遗传因素,这种推测在1998年得到了证实。Guilford等在对一个含25例胃癌患者的Maori血统的家系进行遗传学连锁分析中首次发现:胃癌的发生为常染色体显性遗传;同时在人类第16号染色体长臂,介于D16S3 Jones in 1964 reported a high incidence of gastric cancer in several families of the Maori tribe in New Zealand and he hypothesized that there may be genetic causes. This assumption was confirmed in 1998. For the first time, Guilford and his colleagues found in a genetic linkage analysis of a pedigree of Maori pedigree with 25 cases of gastric cancer that the incidence of gastric cancer was autosomal dominant. At the same time, on the long arm of human chromosome 16, between D16S3