自1977年南京黎磊石提出雷公藤有减少蛋白尿,消水肿的作用以来,至20年后的今天,他的研究有了长足的进展,雷公藤的提取也取得了重大的突破,其免疫抑制的特点被逐步阐明,临床应用范围也逐步拓宽。现就近年来有关雷公藤治疗肾炎的基础与临床文献作一介绍。1 霄公藤的提取 雷公藤最早应用于临床是以煎剂的形式,取雷公藤根去皮粗末,文火煎2小时后过滤,以15g/d服用。因其制作粗糙、去皮不净,副作用明显而受到临床应用的限制。1987年南京总院在动物实验性治疗的基础上进一步观察了雷公藤不同提取物对家兔Masugi肾炎的影响,分别以水、水-醇、雷公藤总甙和雷公藤 Since 1977, Nanjing Lei Lishi proposed tripterygium to reduce proteinuria, elimination of the role of edema, to 20 years later, his research has made considerable progress, extraction of Tripterygium also made a major breakthrough in its immune The characteristics of inhibition were gradually clarified, and the clinical application range was gradually widened. Now in recent years, the basis of triptolide treatment of nephritis and clinical literature for an introduction. The extraction of triptolide Tripterygium was first applied to clinical decoction form, take Tripterygium root peeled rough, simmer for 2 hours and then filtered to 15g / d. Because of its rough production, peeled net, obvious side effects by clinical application of the restrictions. In 1987, Nanjing General Hospital further investigated the effects of different extracts of Tripterygium wilfordii on Masugi nephritis in rabbits on the basis of animal experimental treatment. The effects of water, alcohol, triptolide and triptolide