庆大霉素为氨基甙类抗生素,其分子简单,稳定性好,具有广泛的抗菌作用,临床上主要用于大肠杆菌、变形杆菌、绿脓杆菌等革兰氏阴性菌和某些革兰氏阳性球菌金黄色葡萄球菌、肺炎双球菌等引起的肺炎、败血症、泌尿系感染、化脓性脑膜炎等全身感染。但其肾、耳毒性较大,限制了临床使用。国外研究表明,庆大霉素在新生儿体内的半衰期为2～8h,分布容积为0.35～0.50 l/kg,有效浓度4～10gμ/ml,谷浓度超过2μg/ml,峰浓度超过12～15μg/ml时。肾、耳毒性发生率为2～ Gentamicin aminoglycoside antibiotics, its simple molecule, good stability, has a broad antibacterial effect, mainly used in clinical E. coli, Proteus, Pseudomonas aeruginosa and other Gram-negative bacteria and some Gram’s Positive cocci Staphylococcus aureus, pneumococcal pneumonia caused by pneumonia, sepsis, urinary tract infection, purulent meningitis and other systemic infections. However, its kidney, ototoxicity, limiting the clinical use. Foreign studies have shown that the half-life of gentamicin in neonates is 2 ~ 8h, the volume of distribution is 0.35 ~ 0.50 l / kg, the effective concentration of 4 ~ 10gμ / ml, the trough concentration of more than 2μg / ml, the peak concentration of more than 12 ~ 15μg / ml. Kidney, ototoxicity incidence of 2 ~