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目的综述Tenomodulin在肌腱组织工程中的研究现状,展望其研究和应用发展方向。方法查阅近年关于Tenomodulin在肌腱组织工程中的相关研究文献,并进行分析总结。结果 Tenomodulin是一种Ⅱ型跨膜蛋白,具有调节肌腱组织发育作用,其C端具有抑制血管发生的活性作用。生物信息学特征分析Tenomodulin cDNA全长1 360 bp,定位于染色体Xq22.1上。多种细胞因子对Tenomodulin的表达具有调控作用,其中与碱性螺旋-环-螺旋转录因子Scleraxis关系最为密切;支架材料的性质、结构等对种子细胞Tenomodulin的表达也具有调控作用;应力负载和传代培养对Tenomodulin的表达具有一定影响。结论 Tenomodulin作为肌腱相对特异性标记分子,开发和利用其C端血管发生抑制作用,将在肌腱组织工程中具有重要应用潜力和前景。
Objective To summarize the research status of Tenomodulin in tendon and tissue engineering, and to find out the direction of its research and application. Methods To review the literature about Tenomodulin in tendon and tissue engineering in recent years, and to analyze and summarize. Results Tenomodulin is a type Ⅱ transmembrane protein that regulates the development of tendon tissue and has an inhibitory effect on angiogenesis at the C-terminus. Bioinformatics Characterization Tenomodulin cDNA is 1 360 bp in length and locates on chromosome Xq22.1. A variety of cytokines play a regulatory role in the expression of Tenomodulin, of which the most closely related to the basic helix-loop-helix transcription factor Scleraxis; the nature and structure of the scaffolds also play a regulatory role in the expression of Tenomodulin; stress loading and passage Culture has some influence on the expression of Tenomodulin. Conclusion As a specific molecular marker of tendon, Tenomodulin develops and utilizes its C-terminal angiogenesis inhibitory effect and will have potential applications and prospects in tendon tissue engineering.