论文部分内容阅读
目的 :观察 1 1 0例痴呆及其他神经系统疾病病人脑脊液中 Tau蛋白和 Aβ1 - 4 2 水平的变化 ,对它们的临床意义进行初步的探讨。方法 :用酶联免疫吸附法 (ELISA)对脑脊液中的上述指标进行检测。结果 :Alzheimer病(AD)组的 Tau蛋白水平与其他神经系统疾病相比有明显升高 ,AD组的 Aβ1 - 4 2 水平有明显下降。结论 :Alzheimer病人脑脊液中的 Tau蛋白及 Aβ1 - 4 2 水平与年龄匹配的对照组相比有明显变化 ,但与非 AD痴呆及其他神经系统疾病有重叠
Objective: To observe the changes of Tau protein and Aβ1 - 4 2 levels in cerebrospinal fluid in 110 cases of patients with dementia and other neurological diseases and to investigate their clinical significance. Methods: The above indexes in cerebrospinal fluid were detected by enzyme - linked immunosorbent assay (ELISA). Results: The level of Tau protein in Alzheimer ’s disease (AD) group was significantly higher than that in other neurological diseases, and the level of Aβ1 - 4 2 in AD group was significantly decreased. Conclusion: Tau protein and Aβ1 - 4 2 in cerebrospinal fluid of patients with Alzheimer ’s disease have obvious changes compared with age - matched control group, but overlap with non - AD dementia and other neurological diseases